Does glucosamine work?
Despite decades of research, scientists continue to question whether taking a supplement with glucosamine or chondroitin – alone or combined – has any clinical benefit for joint health.1 More troubling: there is little evidence to suggest its use in healthy men and women.2

The Big Difference Between UC-II® Undenatured Type II Collagen
vs. Glucosamine + Chondroitin

UC-II® ingredient delivers more joint health benefits, month after month.

Research suggests that UC-II® ingredient reduces overall discomfort and stiffness and increases
physical function (WOMAC score) better than Glucosamine + Chondroitin as early as 60 days.

Joint discomfort
UC-II® vs Glucosamine + Chondroitin

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WOMAC standardized questionnaires were used to evaluate joint discomfort. Lower score indicates better joint health. UC-II® significantly improved joint function, mobility and flexibility compared to placebo and glucosamine + chondroitin using three different assessment tools: WOMAC, VAS and Lequesne functional index.
33% Reduction in WOMAC Score
40% Reduction in VAS Score
20% Reduction in LFI Score


*Lugo JP, et al. Nutr J. 2016;15:14.
1. Vasiliadis HS, Tsikopoulos K. Glucosamine and chondroitin for the treatment of osteoarthritis. World J Orthop. 2017;8(1):1-11. Published 2017 Jan 18. doi:10.5312/wjo.v8.i1.1
2. Henrotin Y, Chevalier X, Herrero-Beaumont G, et al. Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities. BMC Res Notes. 2013;6:115. Published 2013 Mar 26. doi:10.1186/1756-0500-6-115